Tel Aviv University (TAU)- Research Group

Dr. Vered Padler-Karavani

Affiliation
Department of Cell Research and Immunology
The George S. Wise Faculty of Life Science
Center for Nanoscience and Nanotechnology
Laboratory of Glycoimmunology
Tel Aviv University

Contact Information
Dr. Vered Padler-Karavani
Building: Britannia
Room: 306
Mobile: +972-52-395-0566
Office phone: +972-3-640-6737
Office fax: +972-3-642-2046
Lab phone:+972-642-5064
Email: vkaravani@post.tau.ac.il
Home page: http://www.tau.ac.il/lifesci/departments/cell_r/members/padler/padler.html

Mailing adress
The George S.Wise faculty of life sciences
Department of Cell Research and Immunology
Tel Aviv University
Tel Aviv 69978, Israel

Research Interest

Glycan immune recognition and response in health and in disease:
Our lab is studying the mechanisms that govern glycan immune recognition and responses in animal models and in humans, both in vitro and in vivo. We combine glycobiology, immunology, biotechnology and cancer research, and use cutting edge technologies within these disciplines, including glycan microarray and glyco-nanotechnology.

Current interests include:

  • Immunological mechanisms of unique anti-carbohydrate antibodies.
  • Anti-carbohydrate antibodies in mucosal secretions and sera.
  • Novel diagnostics and therapeutics to chronic inflammation mediated diseases.
  • Bio-nanotechnology tools based on glycan recognition.

Selected Publications

Kikkeri R, Padler-Karavani V, Diaz S, Verhagen A, Yu H, Hongzhi C, Langereis MA, Groot RdG, Chen X, Varki A. (2013) Quantum dot nanometal surface energy transfer based biosensing of sialic Acid compositions and linkages in biological samples. Anal Chem 85(8):3864-3870.

Padler-Karavani V, Tremoulet AH, Yu H, Chen X, Burns JC, Varki A. (2013) A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. PLoS One. 2013;8(3):e58443

Padler-Karavani V, Song X, Yu H, Hurtado-Ziola N, Huang S, Muthana S, Chokhawala HA, Cheng J, Verhagen A, Langereis MA, Kleene R, Schachner M, de Groot RJ, Lasanajak Y, Matsuda H, Schwab R, Chen X, Smith DF, Cummings RD, Varki A. (2012) Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. J Biol Chem. 287(27):22593-22608.

Lu Q, Padler-Karavani V, Yu H, Chen X, Wu SL, Varki A, Hancock WS. (2012) LC -MS analysis of polyclonal human anti-Neu5Gc xeno-autoantibodies immunoglobulin G Subclass and partial sequence using multistep intravenous immunoglobulin affinity purification and multienzymatic digestion. Anal Chem. 84(6):2761-2768.

Padler-Karavani V, Hurtado-Ziola N, Pu M, Yu H, Huang S, Muthana S, Chokhawala HA, Cao H, Secrest P, Friedmann-Morvinski D, Singer O, Ghaderi D, Verma IM, Liu YT, Messer K, Chen X, Varki A, Schwab R. (2011) Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Res. 71(9):3352-3363.

Padler-Karavani V, Varki A. (2011) Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk. Xenotransplantation. 18(1):1-5.

Ghaderi D, Taylor RE, Padler-Karavani V, Diaz S, Varki A. (2010) Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins. Nat Biotechnol. 28(8):863-867.

Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A. (2010) Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J Exp Med. 207(8):1637-1646. Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. (2009) Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 114(25):5225-5235.

Padler-Karavani V, Yu H, Cao H, Chokhawala H, Karp F, Varki N, Chen X, Varki A. (2008) Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease. Glycobiology. 18(10):818-830.

Full list of publication

Research Groups

Tel Aviv University (TAU)

Ben-Gurion University of the Negev (BGU)

The Hebrew University of Jerusalem (HUJI)

Bar-Ilan University (BIU)

The Chaim Sheba Medical Center (SMC)