The Chaim Sheba Medical Center (SMC)- Research Group

Prof. Jonathan Leor

Director Neufeld Cardiac Research Institute, Tel Aviv University
Director of Tamman Cardiovascular Research Institute, Center of Regenerative
medicine, Stem Cells, and Tissue Engineering, Sheba Medical Center,
Tel-Hashomer, Israel

Affiliation
Professor of Cardiology, Sackler Faculty of Medicine, Tel-Aviv University
Neufeld Cardiac Research Institute, Tel-Aviv University
Tamman Cardiovascular Research Institute
Center of Regenerative medicine, Stem Cells, and Tissue Engineering
Sheba Medical Center, Tel-Hashomer

Contact Information
Prof. Jonathan Leor
Building: Heart Center
Room: with a view
Office phone: 972-8-5302614
Lab phone: 972-530-8439
Office fax: 972-8-5351139
Email: jonathan.leor@sheba.health.gov.il, leorj@post.tau.ac.il

Mailing adress
Heart Center
Sheba Medical Center,
Tel-Hashomer
Israel 5265601

Research Interest

Our lab is studying the biology of myocardial infarction, both in defining the molecular mechanisms that underlie the infarct healing processes, and in developing molecular and cell-based approaches to improve infarct repair. We are particularly interested in:

  1. Tissue engineering using novel, injectable, bioactive materials and molecules.
  2. Stem cell studies that entail cardiac stem cells, with an aim to develop cellular approaches to regenerate the heart.
  3. Reprogramming of cells ex vivo and in situ, by genetic manipulation or growth factors to improve cell infarct healing.
  4. Regulation of the heart's intrinsic repair response, particularly the role of macrophages.
  5. Molecular imaging, cell tracking and inflammation in the heart.

Selected Publications

Naresh NK, Xu Y, Klibanov AL, Vandsburger MH, Meyer CH, Leor J, Kramer CM, French BA, Epstein FH. (2012) Monocyte and/or macrophage infiltration of heart after myocardial infarction: Mr imaging by using t1- shortening liposomes. Radiology 264: 428-435.

Naresh NK, Ben-Mordechai T, Leor J, Epstein FH. Molecular imaging of healing after myocardial infarction. (2011) Current cardiovascular imaging reports. 4: 63-76.

Harel-Adar T, Ben Mordechai T, Amsalem Y, Feinberg MS, Leor J, Cohen S. Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair. (2011)Proceedings of the National Academy of Sciences of the United States of America. 108: 1827-1832.

Ruvinov E, Leor J, Cohen S. The promotion of myocardial repair by the sequential delivery of IGF-1 and hgf from an injectable alginate biomaterial in a model of acute myocardial infarction.(2011)Biomaterials 32: 565-578.

Shachar M, Tsur-Gang O, Dvir T, Leor J, Cohen S. The effect of immobilized rgd peptide in alginate scaffolds on cardiac tissue engineering. (2011) Acta biomaterialia 7: 152-162.

Ruvinov E, Leor J, Cohen S. The effects of controlled hgf delivery from an affinity-binding alginate biomaterial on angiogenesis and blood perfusion in a hindlimb ischemia model.(2010) Biomaterials 31: 4573-4582.

Itzhaki-Alfia A, Leor J, Raanani E, Sternik L, Spiegelstein D, Netser S, Holbova R, Pevsner-Fischer M, Lavee J, Barbash IM. Patient characteristics and cell source determine the number of isolated human cardiac progenitor cells. (2009) Circulation 120: 2559-2566.

Leor J, Tuvia S, Guetta V, Manczur F, Castel D, Willenz U, Petnehazy O, Landa N, Feinberg MS, Konen E, Goitein O, Tsur-Gang O, Shaul M, Klapper L, Cohen S. Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in swine. (2009) Journal of the American College of Cardiology. 54: 1014- 1023.

Dvir T, Kedem A, Ruvinov E, Levy O, Freeman I, Landa N, Holbova R, Feinberg MS, Dror S, Etzion Y, Leor J, Cohen S. Prevascularization of cardiac patch on the omentum improves its therapeutic outcome. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106: 14990-14995.

Amir G, Miller L, Shachar M, Feinberg MS, Holbova R, Cohen S, Leor J. Evaluation of a peritoneal-generated cardiac patch in a rat model of heterotopic heart transplantation. (2009) Cell transplantation. 18: 275-282.

Ruvinov E, Sharabani-Yosef O, Nagler A, Einbinder T, Feinberg MS, Holbova R, Douvdevani A, Leor J. Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infarcted myocardium. (2008) Fibrogenesis & tissue repair. 1:7.

Tsur-Gang O, Ruvinov E, Landa N, Holbova R, Feinberg MS, Leor J, Cohen S. The effects of peptide-based modification of alginate on left ventricular remodeling and function after myocardial infarction. (2009) Biomaterials. 30:189-195.

Landa N, Miller L, Feinberg MS, Holbova R, Shachar M, Freeman I, Cohen S, Leor J. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts n rat. (2008) Circulation. 117: 1388- 1396.

Barsheshet A, Hod H, Shechter M, Sharabani-Yosef O, Rosenthal E, Barbash IM, Matetzky S, Tal R, Bentancur AG, Sela BA, Nagler A, Leor J. The effects of external counter pulsation therapy on circulating endothelial progenitor cells in patients with angina pectoris. (2008) Cardiology. 110: 160-166.

Amsalem Y, Mardor Y, Feinberg MS, Landa N, Miller L, Daniels D, Ocherashvilli A, Holbova R, Yosef O, Barbash IM, Leor J. Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium. (2007) Circulation. 116: 38-45.

Leor J, Gerecht S, Cohen S, Miller L, Holbova R, Ziskind A, Shachar M, Feinberg MS, Guetta E, Itskovitz-Eldor J. Human embryonic stem cell transplantation to repair the infarcted myocardium. (2007) Heart. 93: 1278- 1284.

Schwarzkopf R, Shachar M, Dvir T, Dayan Y, Holbova R, Leor J, Cohen S. Autospecies and post-myocardial infarction sera enhance the viability, proliferation, and maturation of 3d cardiac cell culture. (2006) Tissue engineering. 12: 3467-3475.

Leor J, Rozen L, Zuloff-Shani A, Feinberg MS, Amsalem Y, Barbash IM, Kachel E, Holbova R, Mardor Y, Daniels D, Ocherashvilli A, Orenstein A, Danon D. Ex vivo activated human macrophages improve healing, remodeling, and function of the infarcted heart. (2006) Circulation. 114: 94-100.

Dardik R, Leor J, Skutelsky E, Castel D, Holbova R, Schiby G, Shaish A, Dickneite G, Loscalzo J, Inbal A. Evaluation of the pro-angiogenic effect of factor xiii in heterotopic mouse heart allografts and fxiii-deficient mice. (2006) Thrombosis and haemostasis. 95: 546-550.

Barbash IM, Leor J, Feinberg MS, Tessone A, Aboulafia-Etzion S, Orenstein A, Ruiz-Cabello J, Cohen JS, Mardor Y. Interventional magnetic resonance imaging for guiding gene and cell transfer in the heart. (2004) Heart. 90: 87-91.

Barbash IM, Chouraqui P, Baron J, Feinberg MS, Etzion S, Tessone A, Miller L, Guetta E, Zipori D, Kedes LH, Kloner RA, Leor J. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: Feasibility, cell migration, and body distribution. (2003) Circulation. 108: 863-868.

Etzion S, Barbash IM, Feinberg MS, Zarin P, Miller L, Guetta E, Holbova R, Kloner RA, Kedes LH, Leor J. Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of myod ex vivo: An unlimited source of cells for myocardial repair. (2002) Circulation. 106:I 125-130.

Full list of publication

Research Groups

Tel Aviv University (TAU)

Ben-Gurion University of the Negev (BGU)

The Hebrew University of Jerusalem (HUJI)

Bar-Ilan University (BIU)

The Chaim Sheba Medical Center (SMC)

  • Jonathan Leor