Modular neuronal networks

This project concerns with a novel approach to pattern cultured neural networks into well defined modular structures. Using these modular networks we are studying the interplay between structure and form in neural networks. We observe that modularity allows neural networks to be connected in a contextual manner: Information is transferred only above a certain threshold in a particular direction. This contextual information transfer depends strongly on the balance between excitation and inhibition.

 
Engineered neuronal circuits: A new platform for studying the role of modular topology
Mark Shein-Idelson, Eshel Ben-Jacob, and Yael Hanein,
Frontiers in Neuroengineering Vol. 4, 10, 2011.
 
Innate synchronous oscillations in freely organized small neuronal circuits
Mark Shein Idelson, Eshel Ben-Jacob, Yael Hanein
PLoS One, 5(12): e14443, 2010, Full text: html
 
Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode array
Mark Shein, Alon Greenbaum, Tamir Gabay,Raya Sorkin, Moshe David-Pur, Eshel Ben-Jacob, Yael Hanein
Biomedical Microdevices, 2008, Full text: pdf
 

Contact Details

Admin: Ms. Sara Ben Arie (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Mail address: Prof. Yael Hanein (This email address is being protected from spambots. You need JavaScript enabled to view it.), School of Electrical Engineering, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, 69978, Israel. 

Office address: (1) EE Building (Map), Office 232 and (2) Center for Nanoscience and Nanotechnology (Map), Office 003.

Labs: (1) EE building, Room: 207, 972-3-6407937, and (2) Center for Nanoscience and Nanotechnology, Rooms: 05, 06, 07, 08, 20, 972-3-6405707, 5709, 8379.

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Neuronal Mechanics

Locust neurons are used to explore mechancial effects affecting neuronal development. We use micro suspended beams and carbon nanotube islands, to monitor the cells.

Carbon Nanotube Neural Interfaces

We are using nanotechnology, in particular carbon nanotube technology, to build interfaces for neuronal system. We use these inetrfaces both for basic investigations as well as to develop new electrodes for future neural implants. 

Neuronal Entanglement

Neurons appear to favor rough surfaces. The underlying mechanisms is not well understood and we are trying using various approaches to explore this effect. Using confocal flourescent imaging we were able to show how neurons and glia cells bind to three dimensional carbon nanotubes suggesting that neurons have an innate tendency to interwine into three dimensional support. 

Engineered Neural Circuits

Engineered neural networks are used to investigate the interplay between function and form in neuronal systems.

Mapping Neuronal Recording and Stimulation

Combined MEA and Ca recordings is used to explore to better understand micro neuronal recording and stimulations.

NanoRectenna

Nanorectennae: A new approach to rectify solar energy.

Flexible micro electrodes

We are using carbon nanotube technology to develop superior flexible electrodes for neuronal interfacing. These electrodes alllow not only simple fabrication scheme but also offer high durability, low stimulation threshold and simple integration with other advanced technologies. 

Yael Hanein, Ph.D. School of Electrical Engineering; Physical Electronics, Tel Aviv University, Tel Aviv 69978, Israel. Phone: +972-3-6407698 Fax: +972-3-6423508