MEA technology

Multi electrode array (MEA) technology is gaining increased attention as a valuable tool in neuroscience. As researchers utilize MEA technology in their investigations, full understanding of the technology, its advantages and disadvantages is of paramount importance. In this project we use a special setup combining MEA recording and simulation with Ca imaging to reveal important insight into MEA technology efficacy. Foremost, we find that micro electrodes record from only a very close proximity from the electrode. Stimulation, on the other hand, targets an entirely different cell population residing at a very large distance away from the electrode. Glia activation is also a very pronounced effect observed by this technique. These effects have to be accounted for  when utilizing MEA technology for neurological experimentations.
 
Optical validation of in-vitro extra-cellular neuronal recordings
Nitzan Herzog, Mark Shein, Yael Hanein,
Journal of Neural Engineering Vol. 8, pp. 056008, 2011.

Contact Details

Admin: Ms. Sara Ben Arie (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Mail address: Prof. Yael Hanein (This email address is being protected from spambots. You need JavaScript enabled to view it.), School of Electrical Engineering, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, 69978, Israel. 

Office address: (1) EE Building (Map), Office 232 and (2) Center for Nanoscience and Nanotechnology (Map), Office 003.

Labs: (1) EE building, Room: 207, 972-3-6407937, and (2) Center for Nanoscience and Nanotechnology, Rooms: 05, 06, 07, 08, 20, 972-3-6405707, 5709, 8379.

Yael Hanein, Ph.D. School of Electrical Engineering; Physical Electronics, Tel Aviv University, Tel Aviv 69978, Israel. Phone: +972-3-6407698 Fax: +972-3-6423508