This project concerns with a novel approach to pattern cultured neural networks into well defined modular structures. Using these modular networks we are studying the interplay between structure and form in neural networks. We observe that modularity allows neural networks to be connected in a contextual manner: Information is transferred only above a certain threshold in a particular direction. This contextual information transfer depends strongly on the balance between excitation and inhibition.

Engineered neuronal circuits: A new platform for studying the role of modular topology
Mark Shein-Idelson, Eshel Ben-Jacob, and Yael Hanein,
Frontiers in Neuroengineering Vol. 4, 10, 2011.
Innate synchronous oscillations in freely organized small neuronal circuits
Mark Shein Idelson, Eshel Ben-Jacob, Yael Hanein
PLoS One, 5(12): e14443, 2010, Full text: html
Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode array
Mark Shein, Alon Greenbaum, Tamir Gabay,Raya Sorkin, Moshe David-Pur, Eshel Ben-Jacob, Yael Hanein
Biomedical Microdevices, 2008, Full text: pdf