Biochemistry Molecular Biology
Ubiquitylation and deubiquitylation are dynamic regulatory signals that can affect proteins activity, localization and fate. Ubiquitylated proteins are recognized by ubiquitin receptors that transmit the information conferred by the new structure of the ubiquitylated protein.
Our lab is focused on the regulation of the ubiquitin signal in protein trafficking - especially in the endocytic and biosynthetic pathways. We are taking structural, biochemical and biophysical approaches to understand the molecular mechanisms of ubiquitin recognition.