Structural Biology of Cellular Signaling
Broadly speaking, we are interested in the structural biology of cellular signaling. We have focused on several systems that play key roles in signal transduction. Our goals are to obtain a mechanistic understanding of these molecules; how they interact, transmit and respond to various cues on the most basic level of physics and chemistry; and how this understanding can forge greater progress in comprehending the general biology to which they are pivotal.
Currently we are researching three major areas:
- Calcium signalling, using voltage-dependent calcium channels and protein calcium sensors.
- Electrical signaling, using voltage-dependent potassium channels.
- Protein signaling, using G-protein regulation, protein kinases, and COP9 signalosome.