Prof. Uri Ashery

Molecular mechanisms of synaptic transmission



Our main focus currently is on the following directions:

Investigating synaptic plasticity processes at the hippocampal mossy fiber synapses:

  • Investigating molecular mechanism of synaptic plasticity.
  • Elucidating mechanisms of cAMP dependent synaptic plasticity.
  • Correlating between synaptic plasticity to learning and memory processes.


Elucidating the mitigating effects of hyperbaric oxygen treatment (HBOT) in Alzheimer's disease (AD) mouse models:

  • Investigating the molecular and cellular mechanisms that are regulated following HBOT in AD mouse models.
  • Exploring the physiological effect of HBOT on synaptic activity and plasticity and on blood flow.

Identifying early biomarkers for Parkinson’s disease (PD):

  • Characterizing early steps in alpha synuclein aggregation.
  • Investigating the effect of alpha synuclein aggregation on neuronal activity.


We employ a wide range of methods including: Electrophysiology, Slice recording, Total Internal Reflection Fluorescence (TIRF), Super resolution microscopy (STORM, STED), Fluorescence Resonance Energy Transfer (FRET), Molecular biology, Model simulation, Multi electrode array (MEA) recording, Immunohistochemistry and Behavioral tests.


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